Publications by topic and year

Rodriguez, D.A.; Kalko, S.; Puig-Vilanova, E et al. Muscle and blood redox status after Exercise training in severe COPD patients. Free Radical Biology and Medicine. 2012; 52: 88 - 94
Cano, I.; Mickael, M.; Gomez-Cabrero, D.; Tegnér, J.; Roca, J.; Wagner, P.D. Importance of mitochondrial PO2in maximal O2 transport and utilization: A theoretical analysis. Respiratory Physiology & Neurobiology. 2013; 189: 477-483.
Gea, J.; Agustí, A.; Roca, J. Pathophysiology of muscle dysfunction in COPD. J Appl Physiol. 2013; 114:1222-1234.

Cano I, Lluch-Ariet M, Gomez-Cabrero D, Maier D, Kalko S, Cascante M, Tegnér J, Miralles F, Herrera D, Roca J; Synergy-COPD consortium. Biomedical research in a Digital Health Framework. J Transl Med. 2014 Nov 28;12 Suppl 2:S10. doi: 10.1186/1479-5876-12-S2-S10 

Cano I, Tényi Á, Schueller C, Wolff M, Huertas Migueláñez MM, Gomez-Cabrero D, Antczak P, Roca J, Cascante M, Falciani F, Maier D. The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research. J Transl Med. 2014 Nov 28;12 Suppl 2:S6. doi:10.1186/1479-5876-12-S2-S6

Gomez-Cabrero D, Lluch-Ariet M, Tegner J, Cascante M, Miralles F, Roca J, consortium tS-C: Synergy-COPD: a systems approach for understanding and managing chronic diseases. Journal of Translational Medicine 2014, 12:S2.. 

Roca J, Vargas C, Cano I, Selivanov V, Barreiro E, Maier D, Falciani F, Wagner P, Cascante M, Garcia-Aymerich J, et al: Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management. Journal of Translational Medicine 2014, 12:S3. 

Gomez-Cabrero D, Menche J, Cano I, Abugessaisa I, Huertas-Miguelanez M, Tenyi A, de Mas I, Kiani N, Marabita F, Falciani F, et al: Systems Medicine: from molecular features and models to the clinic in COPD . Journal of Translational Medicine 2014, 12:S4. 

Burrowes K, Doel T, Brightling C: Computational modeling of the obstructive lung diseases asthma and COPD. Journal of Translational Medicine 2014, 12:S5. 

Miguelanez MMH, Mora D, Cano I, Maier D, Gomez-Cabrero D, Lluch-Ariet M, Miralles F: Simulation environment and graphical visualization environment: a COPD use-case.  Journal of Translational Medicine 2014, 12:S7. 

Lluch-Ariet M, de la Torre A, Vallverdu F, Pegueroles-Valles J: Knowledge sharing in the health scenario. Journal of Translational Medicine 2014, 12:S8. 

Velickovski F, Ceccaroni L, Roca J, Burgos F, Galdiz JB, Marina N, Lluch-Ariet M: Clinical Decision Support Systems (CDSS) for preventive management of COPD patients. Journal of Translational Medicine 2014, 12:S9. 

Cascante M, Pedro de Atauri, David Gomez-Cabreo, Peter Wagner et al. Workforce preparation: the Biohealth computing model for Master and PhD students. Journal of Translational Medicine 2014, 12:S11. 

Miralles F, Gomez-Cabrero D, Lluch-Ariet M, Tegner J, Cascante M, Roca J, consortium S-C: Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project. Journal of Translational Medicine 2014, 12:S12. 
Maltais, F.; Decramer, M.; Casaburi et al. An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2014; 1;189(9):e15-62.
Grosdidier, S.; Ferrer, A.; Faner, R.; Piñero J,; Roca, J.; Cosío, B.; Agustí, A.; Gea, J.; Sanz F.; Furlong, L. Network medicine analysis of COPD multimorbidities. Respiratory Research. 2014;
Davidsen, PK.; Herbert, JM.; Antczak, P et al.: A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. Genome Medicine.2014; 6: 59-66
Cano, I.; Selivanov, V.; Gomez-Cabrero, D.; Tegnér, J.; Roca, J.; Wagner, P.D.; Cascante, M. Oxygen pathway modeling estimates high Reactive oxygen species production above the highest permanent human habitation. PLoS One. 2014; 9: e111068

Cano I, Roca J, Wagner PD. Effects of lung ventilation-perfusion and muscle metabolism-perfusion heterogeneities on maximal O2 transport and utilization. J Physiol. 2015 Apr 15;593(8):1841-56.
Puig-Vilanova E, Martínez-Llorens J, Ausin P, Roca J, Gea J, Barreiro E. Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD. Clin Sci (Lond). 2015;128(12):905-2, DOI: 10.1042/CS20140428
Puig-Vilanova E, Rodriguez DA, Lloreta J, Ausin P, Pascual-Guardia S, Broquetas J, Roca J, Gea J, Barreiro E. Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer. Free Radic Biol Med. 2015; 79:91-108.
Agustí, A.; Antó, J.M.; Auffray, C et al. Personalized Respiratory Medicine: Exploring the Horizon, Addressing the Issues. Ame Journal of Respir and Crit Care Med. 2015;
Tényi, Á.; de Atauri, P.; Gomez-Cabrero, D et al. ChainRank, a chain prioritisation method for contextualisation of biological networks. BMC Bioinformatics. 2016; 9 (17):1-17.
Dueñas-Espín I; Vela E; Pauws S et al. Proposals for enhanced health risk assessment and stratification in an integrated care scenario. BMJ Open. 2016; 6:e010301
Roca J, Cano I, Gomez-Cabrero D, Tegnér J. From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidisciplinary and Translational Analysis of COPD. Methods Mol Biol. 2016;1386:283-303. doi:10.1007/978-1-4939-3283-2_13
Roca, J., 2016. From comorbidities of COPD to identification of shared molecular mechanisms by data integration. BMC Bioinformatics. Nov 22;17(Suppl 15):441. doi: 10.1186/s12859-016-1291-3.
Marín de Mas I, Fanchon E, Papp B, Kalko S, Roca J, Cascante M. Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach. Bioinformatics, Volume 33, Issue 1, 1st January, 95–103, DOI: 10.1093/bioinformatics/btw566

Vela E, Tényi Á, Cano I  et al. Population-based analysis of patients with COPD in Catalonia: a cohort study with implications for clinical management. BMJ Open. March; 6;8(3):e017283, DOI: 10.1136/bmjopen-2017-017283 
Cano I, Tenyi A, Vela E, Miralles F, Roca J. Perspectives on Big Data applications of health information. Curr Opin Syst Biol 2017;3:36–42.
Tényi Á, Vela E, Cano I, Cleries M, Monterde D, Gomez-Cabrero D, Roca J. Risk and temporal order of disease diagnosis of comorbidities in patients with COPD: a population health perspective. BMJ Open Respir Res. 2018 Jun 13;5(1):e000302.
Tényi Á, Cano I, Marabita F, Kiani N, Kalko SG, Barreiro E, de Atauri P, Cascante M, Gomez-Cabrero D, Roca J. Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients.  J Transl Med. 2018 Feb 20;16(1):34.